Andrej Sali Lab
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Andrej Sali Lab |
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Bioinformatics, Computational Structural BiologyWe are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for: 1. predicting the structures of proteins; 2. determining the structures of macromolecular assemblies; 3. annotating the functions of proteins using their structures. This research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.
Selected PublicationsF. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007. C.V. Robinson, A. Sali, W. Baumeister. "Molecular sociology of the cell" Nature 450, 973-982, 2007. F.P. Davis, D.T. Barkan, N. Eswar, J.H. McKerrow, A. Sali. "Host-Pathogen Protein Interactions Predicted by Comparative Modeling" Protein Science 16, 2585-2596, 2007. M. Topf, K. Lasker, B. Webb, H. Wolfson, W. Chiu, A. Sali. "Protein Structure Fitting and Refinement Guided by cryoEM Density" Structure 16(2), 295-307, 2008.
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