Andrej Sali Lab

Our Resources

Bioinformatics, Computational Structural Biology

We are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for:

predicting the structures of proteins;
determining the structures of macromolecular assemblies;
annotating the functions of proteins using their structures.

This research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.

News

Congratulations to Avner:
A. Schlessinger, P. Matsson, J.E. Shima, U. Pieper, S.W. Yee, L. Kelly, L. Apeltsin, R.M. Stroud, T.E. Ferrin, K.M. Giacomini, A. Sali. Comparison of Human Solute Carriers. Protein Sci, in press.

Congratulations to Hao:
H. Fan, J.J. Irwin, B.M. Webb, G. Klebe, B. Shoichet, A. Sali. Molecular Docking Screens Using Comparative Models of Proteins. J Chem Inf Model 48, 2512-2527, 2009.

Congratulations to Libusha:
L. Kelly, U. Pieper, F.A. Hays, N. Eswar, D. Kroetz, K.M. Giacomini, R.M. Stroud, A. Sali. A taxonomic profile of the membrane protein universe. J Struct Funct Genom 10, 269-280, 2009.

Congratulations to Madhu & Ben:
M.S. Madhusudhan, B.M. Webb, M.A. Marti-Renom, N. Eswar, A. Sali. Alignment of multiple protein structures based on sequence and structure features. Protein Engineering, Design, and Selection 22, 569-574, 2009.

Go Dave! Congratulations on your UC Cancer Research Coordinating Committee Fellowship

Andrej becomes Director of QB3 at UCSF

Congratulations to Marc:
L. Ortí, R.J. Carbajo, U. Pieper, N. Eswar, S.M. Maurer, A.K. Rai, G. Taylor, M.H. Todd, A. Pineda-Lucena, A. Sali, M.A. Marti-Renom. A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases 3, e418, 2009.

Congratulations to Mark:
M.E. Peterson, F. Chen, J.G. Saven, D.S. Roos, P.C. Babbitt, A. Sali. Evolutionary constraints on structural similarity in orthologs and paralogs. Protein Sci. 18, 1306-1309, 2009.

Congratulations to Daniel, Keren, Javi, Jeremy and Dina:
D. Russel, K. Lasker, J. Phillips, D. Schneidman-Duhovny, J.A. Velazquez- Muriel, A. Sali. The structural dynamics of macromolecular complexes. Curr. Opin. Cell. Biol. 21, 1-12, 2009.

Selected Publications

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007.
C.V. Robinson, A. Sali, W. Baumeister. "Molecular sociology of the cell" Nature 450, 973-982, 2007.
T. Schwede, A. Sali, B. Honig, M. Levitt, H.M. Berman et al "Outcome of a workshop on applications of protein models in biomedical research." Structure 17, 151-159, 2009.
K. Lasker, M. Topf, A. Sali, H. Wolfson. Inferential optimization for simultaneous fitting of multiple components into a cryoEM map of their assembly. Journal of Molecular Biology 388, 180-194, 2009.

Gallery